Flushing Meadow - Corona Park, Flushing, NY 11368, United States, 26 August 2017 | AAP

Nick Kyrgios’ bid for a maiden grand slam title at the US Open will kick off against compatriot John Millman.

The No.14 seed, who lost the Cincinnati Masters final to Bulgaria’s Grigor Dimitrov last week, was drawn to face the Queenslander in next week’s opening round. Kyrgios then faces a potential fourth round clash against five-time champion and third seed Roger Federer.

Both players find themselves on the same side of the draw as world No.1 Rafael Nadal, with a mouth-watering semifinal looming as a possibility.

On the women’s side, Daria Gavrilova gets her Open tilt under way against a qualifier, as do former world No.1s Venus Williams and Caroline Wozniacki in a women’s draw where eight different players could leave New York atop the world rankings.

Ashleigh Barty, who has had a massive rise in the rankings in a season which also netted her first title, faces 21st seed Ana Konjuh. Rounding out the Australian women’s contingent are Ajla Tomljanovic and Arina Rodionova, who will play Johanna Larrson and Richel Hogenkamp respectively.

Thanasi Kokkinakis will open his campaign against two-time quarter-finalist Janko Tipsarevic, while Bernard Tomic faces 19th seed Gilles Muller.

Jordan Thompson, who beat then-world No.1 Andy Murray in the lead-up to Wimbledon, is up against 13th seed Jack Sock.

Spanish-born Sydney teenager Alex De Minaur has been handed a baptism of fire at Flushing Meadows and will face rising sixth seed Dominic Thiem in his first US Open match.