New York, NY, USA, 27 August 2016 | AAP

Top two Australian Nick Kyrgios and Bernard Tomic are on a third-round collision course after landing in the same segment of the draw at the US Open.

Kyrgios, who has never lost to a lower-ranked or unseeded player at a Grand Slam event, is seeded 14th for the final major of 2016 and will be confident of extending that record against Slovenian-born Briton Aljaz Bedene in the first round.

Tomic, fresh off his win over 2014 runner-up Kei Nishikori in Cincinnati last week, has been seeded 17th and meets Bosnia’s Damir Dzumhur in the opening round for the second year in succession.

The 17th seed prevailed in four sets last year at Flushing Meadows.

Should they come through those matches, and win their second-round encounters, Kyrgios and Tomic would in the last 32 meet in a professional match for the first time.

> US Open men’s singles draw

The winner would face a likely fourth-round meeting with No.3 seed Stan Wawrinka.

Meanwhile, John Millman, who chalked up the biggest win of his career against Richard Gasquet at the Winston-Salem Open in North Carolina on Thursday, has been handed a tough opener against world No.10 Dominic Thiem.

Sydney’s Jordan Thompson meets Dimitry Tursunov with wildcard James Duckworth drawn against world No.64 Robin Hasse of the Netherlands.