Indian Wells, CA, USA, 15 March 2016 | AAP

Bernard Tomic’s problematic right wrist has contributed to a third round exit from the BNP Paribas Open at Indian Wells.

The Australian No.1 struggled throughout his clash with big-serving Canadian Milos Raonic, before retiring injured while trailing 6-2 3-0 on Monday.

Tomic has battled the injury since the Australian Open in January, and lasted just 36 minutes against world No.14 Raonic and won just 18 points.

The 23-year-old was already in doubt for next week’s Miami Open, and was reportedly already set to have scans on the wrist after the match against Raonic.

Tomic’s withdrawal leaves┬áSam Stosur as the only remaining Australian in the singles draws at Indian Wells.

Meanwhile second seed Andy Murray suffered a shock 6-4 4-6 7-6 loss to Argentina’s Federico Delbonis.